Prologue: Hyakkimaru

Both Dororo and Hyakkimaru are playable characters. After a tutorial in which Jyukai teaches Hyakkimaru (and the player) how to use his weapons, Hyakkimaru reaches an isolated village attacked by demons led by a Fiend, Great Horn. After slaying the Fiend, Hyakkimaru gets back his vocal cords, and a cut-scene shows the player the story of Hyakkimaru's birth.

The land was in the midst of a war created by the Fiends. One day, the heaven gods decided to send a child, a Chosen One, to slay the Fiends. The demon gods counter-attacked by corrupting the child's father, samurai Kagemitsu Daigo. In exchange for "the power to bring back peace to the land", each of the fiends takes a body part from the baby, who is then abandoned by his father.

After the cut scene, Hyakkimaru saves a group of people from demons. A girl from the group introduces herself as "the world famous thief" Dororo. Dororo is later saved by the samurai from another Fiend, the Homunculus. Hyakkimaru wins another body part, his left eye, and tells Dororo what he knows of his past.

He had been found and raised by a physician, Jyukai, who built his prosthetic body parts. At the age of 18, Hyakkimaru heard a voice from the heavens, who told him that the fiends created a human with the stolen body parts, and that Hyakkimaru could get back what was stolen from him if he killed the forty-eight fiends or their human creation.

 Fiends


 * Great Horn
 * Homunculus